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Acne conglobata

MedGen UID:
537888
•Concept ID:
C0263442
•
Disease or Syndrome
Synonyms: Acne Conglobata; Acne Conglobatas; Conglobata, Acne; Conglobatas, Acne
SNOMED CT: Acne conglobata (42228007)

Definition

Severe and chronic form of acne characterized by large, burrowing abscesses associated with disfigurement. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcne conglobata

Professional guidelines

PubMed

S2k guideline: Laser therapy of the skin.
Paasch U, Zidane M, Baron JM, Bund T, Cappius HJ, Drosner M, Feise K, Fischer T, Gauglitz G, Gerber PA, Grunewald S, Herberger K, Jung A, Karsai S, Kautz G, Philipp C, Schädel D, Seitz AT, Nast A
J Dtsch Dermatol Ges 2022 Sep;20(9):1248-1267. Epub 2022 Sep 13 doi: 10.1111/ddg.14879. PMID: 36098675
Acne: systemic treatment.
Katsambas A, Papakonstantinou A
Clin Dermatol 2004 Sep-Oct;22(5):412-8. doi: 10.1016/j.clindermatol.2004.03.014. PMID: 15556728
Diagnosis and treatment of rosacea fulminans.
Jansen T, Plewig G, Kligman AM
Dermatology 1994;188(4):251-4. doi: 10.1159/000247160. PMID: 8193395

Recent clinical studies

Etiology

Hidradenitis suppurativa and follicular occlusion syndrome: Where is the pathogenetic link?
Jastrząb B, Szepietowski JC, Matusiak Ł
Clin Dermatol 2023 Sep-Oct;41(5):576-583. Epub 2023 Sep 9 doi: 10.1016/j.clindermatol.2023.08.021. PMID: 37690621
Severe acne and its variants: Exploring its natural history and heritability.
Greywal T, Kusari A, Han AM, Borok J, Proudfoot JA, Ahluwalia J, Friedlander SF
Pediatr Dermatol 2022 Jul;39(4):535-540. Epub 2022 May 18 doi: 10.1111/pde.14990. PMID: 35584791
Acne related to dietary supplements.
Zamil DH, Perez-Sanchez A, Katta R
Dermatol Online J 2020 Aug 15;26(8) PMID: 32941710
SAPHO and CRMO: The Value of Imaging.
Jurik AG, Klicman RF, Simoni P, Robinson P, Teh J
Semin Musculoskelet Radiol 2018 Apr;22(2):207-224. Epub 2018 Apr 19 doi: 10.1055/s-0038-1639469. PMID: 29672809
The SAPHO syndrome revisited with an emphasis on spinal manifestations.
Leone A, Cassar-Pullicino VN, Casale R, Magarelli N, Semprini A, Colosimo C
Skeletal Radiol 2015 Jan;44(1):9-24. Epub 2014 Oct 21 doi: 10.1007/s00256-014-2025-0. PMID: 25331355

Diagnosis

An Up-to-Date Approach to the Management of Dissecting Cellulitis.
Nussbaum D, Desai S, Nelson K, Saardi K, Friedman A
J Drugs Dermatol 2022 Jul 1;21(7):800-802. doi: 10.36849/JDD.0421. PMID: 35816064
Severe acne and its variants: Exploring its natural history and heritability.
Greywal T, Kusari A, Han AM, Borok J, Proudfoot JA, Ahluwalia J, Friedlander SF
Pediatr Dermatol 2022 Jul;39(4):535-540. Epub 2022 May 18 doi: 10.1111/pde.14990. PMID: 35584791
SAPHO and CRMO: The Value of Imaging.
Jurik AG, Klicman RF, Simoni P, Robinson P, Teh J
Semin Musculoskelet Radiol 2018 Apr;22(2):207-224. Epub 2018 Apr 19 doi: 10.1055/s-0038-1639469. PMID: 29672809
Difficult and rare forms of acne.
Dessinioti C, Katsambas A
Clin Dermatol 2017 Mar-Apr;35(2):138-146. Epub 2016 Oct 27 doi: 10.1016/j.clindermatol.2016.10.005. PMID: 28274350
The SAPHO syndrome revisited with an emphasis on spinal manifestations.
Leone A, Cassar-Pullicino VN, Casale R, Magarelli N, Semprini A, Colosimo C
Skeletal Radiol 2015 Jan;44(1):9-24. Epub 2014 Oct 21 doi: 10.1007/s00256-014-2025-0. PMID: 25331355

Therapy

Acne fulminans and its multiple associated factors: a systematic review.
Trave I, Donadoni R, Cozzani E, D'Agostino F, Herzum A, Parodi A
Eur J Dermatol 2023 Dec 1;33(6):624-634. doi: 10.1684/ejd.2023.4629. PMID: 38465543
Severe acne and its variants: Exploring its natural history and heritability.
Greywal T, Kusari A, Han AM, Borok J, Proudfoot JA, Ahluwalia J, Friedlander SF
Pediatr Dermatol 2022 Jul;39(4):535-540. Epub 2022 May 18 doi: 10.1111/pde.14990. PMID: 35584791
Acne related to dietary supplements.
Zamil DH, Perez-Sanchez A, Katta R
Dermatol Online J 2020 Aug 15;26(8) PMID: 32941710
Acne: systemic treatment.
Katsambas A, Papakonstantinou A
Clin Dermatol 2004 Sep-Oct;22(5):412-8. doi: 10.1016/j.clindermatol.2004.03.014. PMID: 15556728
Dapsone-induced jaundice.
Stone SP, Goodwin RM
Arch Dermatol 1978 Jun;114(6):947. PMID: 666334

Prognosis

Severe acne and its variants: Exploring its natural history and heritability.
Greywal T, Kusari A, Han AM, Borok J, Proudfoot JA, Ahluwalia J, Friedlander SF
Pediatr Dermatol 2022 Jul;39(4):535-540. Epub 2022 May 18 doi: 10.1111/pde.14990. PMID: 35584791
Cutaneous hemophagocytosis: Clinicopathologic features of 21 cases.
Boggio F, Lora V, Cota C, Pereira A, Müllegger R, Prieto-Torres L, Cerroni L
J Am Acad Dermatol 2018 Feb;78(2):377-382. doi: 10.1016/j.jaad.2017.08.041. PMID: 29332707
SAPHO syndrome in an adolescent: a clinical case with unusual severe systemic impact.
Freira S, Fonseca H, Ferreira PD, Vasconcelos P, Fonseca JE
J Adolesc Health 2014 Aug;55(2):304-6. Epub 2014 Apr 13 doi: 10.1016/j.jadohealth.2014.02.004. PMID: 24726464
SAPHO: syndrome or concept? Imaging findings.
Earwaker JW, Cotten A
Skeletal Radiol 2003 Jun;32(6):311-27. Epub 2003 Apr 29 doi: 10.1007/s00256-003-0629-x. PMID: 12719925
A case of dissecting cellulitis and a review of the literature.
Scheinfeld NS
Dermatol Online J 2003 Feb;9(1):8. PMID: 12639466

Clinical prediction guides

Severe acne and its variants: Exploring its natural history and heritability.
Greywal T, Kusari A, Han AM, Borok J, Proudfoot JA, Ahluwalia J, Friedlander SF
Pediatr Dermatol 2022 Jul;39(4):535-540. Epub 2022 May 18 doi: 10.1111/pde.14990. PMID: 35584791
Short-term clinical effects of photodynamic therapy with topical 5-aminolevulinic acid for facial acne conglobata: an open, prospective, parallel-arm trial.
Yang GL, Zhao M, Wang JM, He CF, Luo Y, Liu HY, Gao J, Long CQ, Bai JR
Photodermatol Photoimmunol Photomed 2013 Oct;29(5):233-8. doi: 10.1111/phpp.12059. PMID: 24001378
Acne conglobata and Klinefelter's syndrome.
Wollenberg A, Wolff H, Jansen T, Schmid MH, Röcken M, Plewig G
Br J Dermatol 1997 Mar;136(3):421-3. PMID: 9115930
Dapsone-induced jaundice.
Stone SP, Goodwin RM
Arch Dermatol 1978 Jun;114(6):947. PMID: 666334
Acne conglobata; use of cortisone and corticotropin in therapy.
FARBER EM, CLAIBORNE ER
Calif Med 1954 Aug;81(2):76-8. PMID: 13182626Free PMC Article

Recent systematic reviews

Acne fulminans and its multiple associated factors: a systematic review.
Trave I, Donadoni R, Cozzani E, D'Agostino F, Herzum A, Parodi A
Eur J Dermatol 2023 Dec 1;33(6):624-634. doi: 10.1684/ejd.2023.4629. PMID: 38465543
Analyzing the Efficacy of Isotretinoin in Treating Dissecting Cellulitis: A Literature Review and Meta-Analysis.
Guo W, Zhu C, Stevens G, Silverstein D
Drugs R D 2021 Mar;21(1):29-37. Epub 2021 Jan 2 doi: 10.1007/s40268-020-00335-y. PMID: 33387328Free PMC Article

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